R&D SCIENCE@HOME l Gold&Snow Worldwide Inc.

Executive Summary

			Science@Home Inc. is a company that commercializes the patented technology of Professor Lee Yoon-Sik in the Chemical and Biological Engineering department of Seoul National University and was established as a subsidiary of Seoul National University Technology Holdings.

			Based on technology and know-how related to solid phase peptide production, the company is planning to discover various physiological active peptides and utilize self-assembled peptides (tyrosine rich peptides) that represent new properties, especially in combination with various materials.

			YC7-HA BioGel, based on hyaluronic acid, is a new cladding with the multi-functional form of an ointment and bandage, which can be used as skin wound treatment agent, functional cosmetic patch, and burn therapy using the effect of replacing the discomfort of conventional patch or bandages.

			In addition, self-assembled peptides are introduced on the surface of metal nanoparticles to prevent the toxicity of nanoparticles and maximize their biocompatibility and effectiveness, enabling them to be utilized in new treatments and diagnostic technologies.

Executive Summary

Science@Home Inc. is a company that commercializes the patented technology of Professor Lee Yoon-Sik in the Chemical and Biological Engineering department of Seoul National University and was established as a subsidiary of Seoul National University Technology Holdings.
Based on technology and know-how related to solid phase peptide production, the company is planning to discover various physiological active peptides and utilize self-assembled peptides (tyrosine rich peptides) that represent new properties, especially in combination with various materials
YC7-HA BioGel, based on hyaluronic acid, is a new cladding with the multi-functional form of an ointment and bandage, which can be used as skin wound treatment agent, functional cosmetic patch, and burn therapy using the effect of replacing the discomfort of conventional patch or bandages
In addition, self-assembled peptides are introduced on the surface of metal nanoparticles to prevent the toxicity of nanoparticles and maximize their biocompatibility and effectiveness, enabling them to be utilized in new treatments and diagnostic technologies.

Company Overview

CEO

Changrok Oh

Date of establishment

October 7, 2010

Address

133-100 Gwanak-ro 1, Seoul National University,

Gwanak-ro 1, Gwanak-gu, SEOUL, South Korea

Core Technology

Science@Home Inc. was established for commercializing patented technology on the research result of Professor Lee Yoon-sik, Chemical and Biological Engineering Department of Seoul National University, and has the know-how for developing new bio-nanomaterials and effective screening system.
As a subsidiary of Seoul National University Technology Holdings, it has established a research and development platform to industrialize related patent technologies.
The core technology is to develop smart bio-materials based on self-assembled peptide, has also accumulated experience of the solid phase peptide synthesis and manufacturing peptides.

Company Overview

CEO

Changrok Oh

Date of establishment

October 7, 2010

(Capital: 100 million won, 20,000 shares)

Address

133-100 Gwanak-ro 1, Seoul National University, Gwanak-ro 1, Gwanak-gu, SEOUL, South Korea

Core Technology

Science@Home Inc. was established for commercializing patented technology on the research result of Professor Lee Yoon-sik, Chemical and Biological Engineering Department of Seoul National University, and has the know-how for developing new bio-nanomaterials and effective screening system.
As a subsidiary of Seoul National University Technology Holdings, it has established a research and development platform to industrialize related patent technologies.
The core technology is to develop smart bio-materials based on self-assembled peptide, has also accumulated experience of the solid phase peptide synthesis and manufacturing peptides.

Business Model

PEPTIDE Platform Biz from production to application of peptides

Peptide Production

Process establishment from g scale synthesis to GMP scale production

Exploration of New Peptides

Screening new peptides for bio-active and functional applications

Peptide Application

Development of products with new bio-active peptides

Biogel of YC7 PEPTIDE Cross-linked with Hyaluronic Acid

PEPTIDE Application

Tyrosine as Cross-linker in Protein (Resilin)

Tyrosine residues are known to play an important function in resillin and gluten, an elastic protein that is often present in the legs of fleas and wing muscles of dragonflies.
Cross-linking or covalent bonding of tyrosines in the proteins leads to a folding structure, which maintains the high level of protein intensity and storage modulus. This means that tyrosine-based peptide materials are biocompatible in the form of biogel

Tyrosine as Cross-linker in Protein

(Resilin)

Tyrosine residues are known to play an important function in resillin and gluten, an elastic protein that is often present in the legs of fleas and wing muscles of dragonflies.
Cross-linking or covalent bonding of tyrosines in the proteins leads to a folding structure, which maintains the high level of protein intensity and storage modulus. This means that tyrosine-based peptide materials are biocompatible in the form of biogel

YC7 PEPTIDE : Self-Assembly Peptide

YC7 PEPTIDE is one of tyrosine rich peptides that contain a lot of tyrosines, which is a self-assembly characteristic that creates a three-dimensional structure on its own due to intermolecular forces in the solution and can be formed by various structures such as nano-scale spherical, fibrous, and film structures according to conditions.

In particular, the nano-film formed is strong enough to overcome the surface tension of the aqueous solution and forms a multilayered structure that can be stacked according to the peptide concentration in the solution (the thickness of the fault structure is about 1.4 nm, and the thickness varies according to the number of layers, and approximately 50-400 nm)

Due to the non-cytotoxic and biocompatible properties, YC7 PEPTIDE can be applied to various bio-materials, especially used as a binding layer between heterogeneous biomaterials. It can be used for bio-materials such as elastic hydrogels, reactive drug delivery vesicles, floating scafolds for cell culture, ion selective membranes, and protein-mimic catalysts.

YC7 PEPTIDE : Self-Assembly Peptide

YC7 PEPTIDE is one of tyrosine rich peptides that contain a lot of tyrosines, which is a self-assembly characteristic that creates a three-dimensional structure on its own due to intermolecular forces in the solution and can be formed by various structures such as nano-scale spherical, fibrous, and film structures according to conditions.
In particular, the nano-film formed is strong enough to overcome the surface tension of the aqueous solution and forms a multilayered structure that can be stacked according to the peptide concentration in the solution (the thickness of the fault structure is about 1.4 nm, and the thickness varies according to the number of layers, and approximately 50-400 nm)
Due to the non-cytotoxic and biocompatible properties, YC7 PEPTIDE can be applied to various bio-materials, especially used as a binding layer between heterogeneous biomaterials. It can be used for bio-materials such as elastic hydrogels, reactive drug delivery vesicles, floating scafolds for cell culture, ion selective membranes, and protein-mimic catalysts.

YC7 PEPTIDE

YC7 PEPTIDE molecules represent the characteristics of self-assembly, creating a three-dimensional structure of their own in the aqueous solution.

It forms nano-film on the interface of the aqueous solution and the air and shows high strength to overcome the surface tension of water.

Self-Assembly Peptide

The mixture formulation of hyaluronic acid and YC7 PEPTIDE resulted in a significantly improved biogel (YC7-HA Biogel) with elasticity and strength after photo-reaction.

The YC7-HA Biogel confirmed that storage modulus (G') and complex visibility (Ƞ*) have more than doubled.

The biogel cross-linked by enzymes or without Y7 peptides is completely non-elastic and crumbly.

Natural Photo-synthesis Cosmetics

NEXT R&D Project - 1

The Efficacy of Natural Photosynthetic Pigment

Plants generally produce organic matter and energy needed for growth in chlorophyll through photosynthesis with sunlight

In addition to plants, phototrophs grow by converting light energy into bioenergy in the form of microelectronic energy using natural pigments similar to chlorophyll in the body.

It is a substance that is synthesized and excreted in the human body and is often present in the yellow stripes of honeybees and wasps

David Bergman, a professor of physics at Tel Aviv University in Israel, confirms that a honeybee or wasp creates bio-energy through photosynthesis using the yellow stripes on the belly. (Ref. Naturwissenschaften, December 2010, Vol. 97, Iss. 12, pp 1067–1076)

The reason honeybees can be active during the daytime when sunlight is strong even without feeding, is because they convert light energy into micro-electrical energy through photosynthetic natural pigments to produce bio-energy needed for the metabolism.

The Efficacy of Natural Photosynthetic Pigment

Plants generally produce organic matter and energy needed for growth in chlorophyll through photosynthesis with sunlight
In addition to plants, phototrophs grow by converting light energy into bioenergy in the form of microelectronic energy using natural pigments similar to chlorophyll in the body.
It is a substance that is synthesized and excreted in the human body and is often present in the yellow stripes of honeybees and wasps
David Bergman, a professor of physics at Tel Aviv University in Israel, confirms that a honeybee or wasp creates bio-energy through photosynthesis using the yellow stripes on the belly. (Ref. Naturwissenschaften, December 2010, Vol. 97, Iss. 12, pp 1067–1076)
The reason honeybees can be active during the daytime when sunlight is strong even without feeding, is because they convert light energy into micro-electrical energy through photosynthetic natural pigments to produce bio-energy needed for the metabolism.

Natural Photosynthesis Cosmetics

Research on skin regeneration and anti-aging using these micro-electrical energy have been actively studied in medical and beauty application.

The micro-electrical energy that can make cell membrane potential difference increases adenosine triphosphate (ATP) and protein production in the cell and induces cell restoration and healing.

When light is received while using a mask pack, microelectronic energy is generated to regenerate cells and improve wrinkles without other mechanical devices.

Activity of Oriental Hornet

Confirm that the stronger the sunlight, the greater the activity of the honeybees
lBy producing the energy required through sunlight, continuously active for several miles
lReleased to BBC News in the UK
lRef. Oriental hornets powered by 'solar energy‘
Monday, 6 December 2010

Activity of Oriental Hornet

lConfirm that the stronger the sunlight, the greater the activity of the honeybees
lBy producing the energy required through sunlight, continuously active for several miles
lReleased to BBC News in the UK
lRef. Oriental hornets powered by 'solar energy‘
Monday, 6 December 2010

Production of Micro-voltage from Natural Photo-synthesis Dye

Light Emitting Plant

NEXT R&D Project - 2

Bio-luminescence

Joaquim C. G. Esteves da Silva researchers (University of Porto) have identified the entire structure called Bioluminescence in the glowing process of firefly that the precursor of Luciferin oxidizes through the metabolic process of the Luciferase enzyme.

This bio-light emiting process is a phenomenon in which living things emit light through chemical processes, and is highly efficient with a luminous efficiency of 40-90%. There is no heat generated unlike artificial lighting, so it is also called cold light.

Recently the bio-lighting system using Luciferin has been used to identify light-sensitive cells or tissues in bio-imaging and to track specific gene expression in genetic engineering.

Since the early 2000s, bio-lighting systems have been studied. Philips has developed home lighting using E. coli bacteria, and Glowee, a French company, has developed bio-lighting for front signs of the store and city road as the main market, but the maximum duration was as short as three days, which caused economic problems.

The research of bio-luminescence process has been expanded to plants in addition to bacteria, insects and marine biomass. Genetic manipulation have been applied to some tobacco crops for bioluminescence, but the study was halted due to safety problems and difficulties in mass production caused by the transformation of genetic modification.

Bio-luminescence

Joaquim C. G. Esteves da Silva researchers (University of Porto) have identified the entire structure called Bioluminescence in the glowing process of firefly that the precursor of Luciferin oxidizes through the metabolic process of the Luciferase enzyme.
This bio-light emiting process is a phenomenon in which living things emit light through chemical processes, and is highly efficient with a luminous efficiency of 40-90%. There is no heat generated unlike artificial lighting, so it is also called cold light..
Recently the bio-lighting system using Luciferin has been used to identify light-sensitive cells or tissues in bio-imaging and to track specific gene expression in genetic engineering.
Since the early 2000s, bio-lighting systems have been studied. Philips has developed home lighting using E. coli bacteria, and Glowee, a French company, has developed bio-lighting for front signs of the store and city road as the main market, but the maximum duration was as short as three days, which caused economic problems.
The research of bio-luminescence process has been expanded to plants in addition to bacteria, insects and marine biomass. Genetic manipulation have been applied to some tobacco crops for bioluminescence, but the study was halted due to safety problems and difficulties in mass production caused by the transformation of genetic modification.

Light Emitting Plant by Bio-luminescence

The bio-compatible nanoparticles, which combine Luciferin and Luciferase enzymes, are prepared and injected into plants.

The bio-lighting system is maintained for about four hours using adenosine triphosphate (ATP), as an energy source for lightening, produced from the photosynthesis of plants.

Light Emitting Plant by Bio-luminescence

The bio-light emitting system based on nano-bionic technology can be applied without limitation to a variety of plants, compared to the fact that genetically engineered systems were restricted to tobacco plants.

Also, it is a non-genetically modified plant, so it is widely available in natural environment because there are no serious safety problems or concerns of pollution.